Saved Dopamine transporter Assignment | College Homework Help

Question 1 (10 points) ✓ Saved Dopamine transporter (DAT) in normal (A), early Parkinson’s (B) and late stage Parkinsons’ (C) brains. Source: Lancet Parkinson’s disease is a neurological disease that is associated with low levels of the neurotransmitter dopamine in the basal ganglia (see picture above). Under normal conditions, dopamine binds to dopamine type 1 (D1) receptors, a type of G-protein coupled receptors. When activated, D1 receptors stimulate adenylyl cyclase and ultimately depolarize the post-synaptic cell. Based on this information, what would you expect when dopamine is LOW? Higher than normal CAMP in the post-synaptic cell. Increased activation of protein kinase A (PKA) in the post-synaptic cell. Higher than normal membrane potential in the post-synaptic cell. Decreased likelihood of generating action potentials in the post-synaptic cell. Increased activation of adenylyl cyclase in the post-synaptic cell.
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