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Part II – Paxton’s Hypotheses about HIV-Protected Individuals Paxton and his colleagues had a few hypotheses about why some of the individuals exposed to HIV were protected against this virus. CD8+ lymphocyte inhibition of HIV-1 replication (“Super Cytotoxic T Cells” Hypothesis) Perhaps the reason that some individuals were protected against HIV is because they had cytotoxic T cells that were better and faster at recognizing infected T helper cells. Tis ability allowed the immune system to rid the body of any HIV infection before the virus could replicate inside T helper cells and transform these cells into HIV factories. CD4+ infectibility and efciency of viral replication (“Super T Helper Cells” Hypothesis) Perhaps the T helper cells of the protected individuals were diferent, preventing the infection and replication of the virus inside the cell. Tere are many steps necessary for viral infection and replication inside T helper cells and any of them could be impeded.

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Questions 1. Classify each of your proposed hypotheses into the two categories proposed by Paxton and his colleagues (Note: some hypotheses may ft into neither category).

2. How might you test each of your hypotheses? Propose an experiment. What are your controls? Experimental conditions? “Resistance Is Futile … or Is It?” by Annie Prud’homme-Généreux.. Get  Nursing Assignments  Help Today

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